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Hotel History

Anchored by its position on the National Register of Historic Places, and once advertised as the only transient hotel between Philadelphia and Lancaster, the Wayne Hotel is an established landmark in the heart of Philadelphia’s western Main Line suburbs.

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Virtual Tour

Take a tour of the Wayne Hotel and have a look around, literally. Our 360° Virtual Tours of the common areas, Restaurant, Guest Rooms, and Private Event Rooms will walk you through the property, so you can get acquainted before you even step foot through the door.

Take a Look Around


Serving the Main Line for over 35 years, the Wayne Hotel has earned an award-winning reputation as a first-class hotel with exceptional service. Accolades include awards from TripAdvisor, Main Line Today, Philadelphia Style, and Philadelphia Magazine.

Awards & Recent Press


Guest Rooms & Suites

With 40 beautifully restored and upgraded Guest Rooms, including 2 unique Luxury Suites, the Wayne Hotel is a boutique alternative to traditional hotel accommodations and is the perfect choice for your next visit to Philadelphia’s Main Line.

View Our Overnight Accommodations


Book online or reserve your room by phone. Wayne Hotel Guest Service Representatives are available to book your hotel reservation 24 hours daily to offer you the lowest rates and helpful local information.

Call 610-687-5000 or Book Online

Location & Directions

The Wayne Hotel is conveniently located 18 miles west of Philadelphia in downtown Wayne, PA on Lancaster Ave (Route 30) and is easily accessible by all major transportation routes and public transit, including the SEPTA Regional Rail which is only 1.5 blocks from the Wayne Hotel.

Location & Driving Directions


If you have questions or need assistance, contact us anytime. Front Desk agents are available 24/7.